GLP-1 Receptor Agonists

GLP-1 receptor agonists are a class of medications including semaglutide (Ozempic, Wegovy) and liraglutide (Saxenda, Victoza) that were originally developed for type 2 diabetes but are increasingly used for PCOS management due to their significant effects on insulin resistance, weight loss, and metabolic health. These drugs mimic the natural GLP-1 hormone to enhance insulin secretion, slow gastric emptying, and reduce appetite, addressing several core aspects of PCOS simultaneously. Emerging research suggests that GLP-1 medications can improve menstrual regularity, reduce androgen levels, lower inflammation, and support fertility in women with PCOS, though they are primarily prescribed off-label for this purpose.