Inositol

Inositol is a vitamin-like compound that exists in two primary forms—myo-inositol and D-chiro-inositol—that play crucial roles in insulin signaling and have become among the most widely researched supplements for PCOS management. Studies show that inositol supplementation can improve insulin sensitivity, support ovulation, reduce androgen levels, and help regulate menstrual cycles, with effects sometimes comparable to metformin but with fewer side effects. The combination of both forms in the body's natural 40:1 ratio (40 parts myo-inositol to 1 part D-chiro-inositol) appears to be more effective than either form alone for PCOS symptom management.