Berberine

Berberine is a natural alkaloid compound extracted from plants like goldenseal, barberry, and Oregon grape that has shown powerful insulin-sensitizing effects comparable to the prescription medication metformin in clinical studies. In women with PCOS, berberine supplementation (typically 500 mg two to three times daily) can improve insulin resistance, lower fasting blood sugar and insulin levels, reduce testosterone, support weight management, and improve lipid profiles. As a natural alternative with a growing evidence base, berberine is increasingly recognized by integrative practitioners as an effective option for managing PCOS metabolic dysfunction, though it should be discussed with a healthcare provider as it can interact with certain medications.