Spironolactone

Spironolactone is an anti-androgen medication that blocks testosterone and other androgens from binding to receptors in the skin and hair follicles, making it highly effective for managing PCOS symptoms like hirsutism, hormonal acne, and androgenetic alopecia. Originally developed as a blood pressure medication and diuretic, it works by both blocking androgen receptors and reducing androgen production, with visible improvement in skin and hair symptoms typically appearing after 3-6 months of consistent use. Because spironolactone can cause birth defects, it must be used alongside reliable contraception and is often prescribed in combination with birth control pills for dual hormonal benefit.